Insulin-Like Growth Factor-1 Receptor Inhibitors: A Potential Cancer Treatment
نویسندگان
چکیده
منابع مشابه
Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth.
The insulin-like growth factor-1 receptor (IGF-1R) plays a pivotal role in transformation, growth, and survival of malignant cells, and has emerged as a general and promising target for cancer treatment. However, no fully selective IGF-1R inhibitors have thus far been found. This is explained by the fact that IGF-1R is highly homologous to the insulin receptor, coinhibition of which may cause d...
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ژورنال
عنوان ژورنال: ACS Medicinal Chemistry Letters
سال: 2012
ISSN: 1948-5875,1948-5875
DOI: 10.1021/ml300406n